Publications
Publications
2025
The PARP1-EXD2 axis orchestrates R-loop resolution to safeguard genome stability
Li Z, Liu Y, Liu Y, Zhang Y, Huen MS, Lu H, Zhang Z, Zhou J, Fang D, Liu T, Huang J.
Nat Chem Biol 2025 (Online ahead of print)
2025
Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cacner
Tsoi H, Leung GM, Man EP, You CP, Cheung KH, Chan KY, Gong C, Huen MS, Khoo US
J Transl Med 2025; 23: 860.
2024
Kim JE, Pan X, Tse KY, Chan HH, Dong C, Huen MS.
Nucleic Acids Res 2024; 52(17): 10297-10310.
2024
Li J, Xiong N, West KL, Leung M, Ching YP, Huang J, Yuan J, Yu CH, Leung JW, Huen MS.
Nucleic Acids Res 2024; 52(15): 8897-8912.
2024
Ng RR, Lin Z, Zhang Y, Ti SC, Javed A, Wong JW, Fang Q, Leung JW, Tang AH, Huen MS.
Sci Adv 2024; 10(29): eadm9577.
2024
Inhibition of aberrantly overexpressed Polo-like kinase 4 is a potential effective treatment for DNA damage repair-deficient uterine leiomyosarcoma
Lee HH, Chow KL, Wong HS, Chong TY, Wong AS, Cheng GH, Ko JM, Siu HC, Yeung MC, Huen MS, Tse KY, Bray MR, Mak TW, Leung SY, Ip PP.
Clin Cancer Res 2024; 30(17): 3904-3918.
2024
Synergistic anticancer effect by targeting CDK2 and EGFR-ERK signaling
Wu J, Chen Y, Li R, Guan Y, Chen M, Yin H, Yang X, Jin M, Huang B, Ding X, Yang J, Wang Z, He Y, Wang Q, Luo J, Wang P, Mao Z, Huen MS, Lou Z, Yuan J, Gong F.
J Cell Biol 2024; 223(1): e202203005.
2023
Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML
Man CH, Lam W, Dang CC, Zeng XY, Zheng LC, Chan NN, Ng KL, Chan KC, Kwok TH, Ng TC, Leung WY, Huen MS, Wong CC, So CWE, Dou Z, Goyama S, Bray MR, Mak TW, Leung AY.
Blood 2023; 142(23): 2022-2015.
2022
Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies
Fang H, Yan HH, Bilardi RA, Flensburg C, Yang H, Barbour JA, Siu HC, Turski M, Chew E, Xu Z, Lam ST, Sharma R, Xu M, Li J, Ip HW, Cheung CY, Huen MS, Sweet-Cordero EA, Majewski IJ, Leung SY, Wong JW.
Genome Med 2022; 14(1): 124.
2022
RNF4 controls the extent of replication fork reversal to preserve genome stability
Ding L, Luo Y, Tian T, Chen X, Yang Y, Bu M, Han J, Yang B, Yan H, Liu T, Wu M, Zhang G, Xu Y, Zhu S, Huen MS, Mao G, Huang J.
Nucleic Acids Res 2022; 50(10): 5672-5687.
2021
Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation
Feng D, Wang J, Yang W, Li J, Lin X, Zha F, Wang X, Ma L, Choi NT, Mii Y, Takada S, Huen MS, Guo Y, Zhang L, Gao B.
Sci Adv 2021; 7(20): eabg2099.
2021
ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP
Han J, Wan L, Jiang G, Cao L, Xia F, Tian T, Zhu X, Wu M, Huen MS, Wang Y, Liu T, Huang J.
PNAS 2021; 118(12): e2022600118.
2021
Dong C, An L, Yu CH, Huen MS.
Nucleic Acids Res 2021; 49(3): 1485-1496.
2021
RECQL5 KIX domain splicing isoforms have distinct functions in transcription repression and DNA damage response
Ding D, Sun X, Pang MY, An L, Huen MS, Hu T, Ishibashi T.
DNA Repair 2021; 97: 103007.
2021
PRMT6 deficiency induces autophagy in hostile microenvironment of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability
Che N, Ng KY, Wong TL, Tong M, Kau PW, Chan LH, Lee TK, Huen MS, Yun JP, Ma S.
Cancer Lett 2021; 501: 247-262.
2020
Dong C, West KL, Tan XY, Li J, Ishibashi T, Yu CH, Sy SM, Leung JW, Huen MS.
PNAS 2020; 117(29): 17019-19030.
2020
Deacetylation of a deacetylase drives the DNA Damage Response
Ng RR, Huen MS.
Genome Instab Dis 2020; 1: 151-154.
2020
The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I
Li M, Feng H, Lin Z, Zheng J, Liu D, Guo R, Li J, Li RHW, Ng RH, Huen MS, Wang PJ, Yeung WS, Liu K.
J Genet Genomics 2020; 47(8): 451-465.
2020
Tan XY, Huen MS.
Essays in Biochemistry 2020; EBC20190094.
2020
Cancer-associated histone mutation H2BG53D disrupts DNA-histone octamer interaction and promotes oncogenic phenotypes
Wan YC, Leung TC, Ding D, Sun X, Lui J, Zhu L, Kang TZ, Yang D, Zhang Y, Zhang J, Qian C, Huen MS, Li Q, Chow MZ, Zheng Z, Han J, Goel A, Wang X, Ishibashi T, Chan KM.
Signal Transduct Target Ther 2020; 5(1): 27.
2020
53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice
Chen J, Li P, Song L, Bai L, Huen MS, Liu Y, Lu LY.
Cell Death Diff 2020; 27(9): 2552-2567.
2020
Preemptive homology-directed DNA repair fosters complex genomic rearrangements in hepatocellular carcinoma
Sy SM, Guo Y, Lan Y, Ng H, Huen MS.
Transl Oncol 2020; 13(9): 100796.
2019
LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation
West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MS, Leung JW.
Nucleic Acids Res 2019; 47(12): 6236-6249.
2019
A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response
Roewenstrunk J, Di Vona C, Chen J, Borras E, Chao D, Arato K, Sabido E, Huen MS, de la Luna S.
Sci Rep 2019; 9(1): 6014.
2018
Chen Y, Li J, Cao F, Lam J, Cheng CC, Yu CH, Huen MS.
Nucleic Acids Res 2018; 46(19): 10119-10131.
2018
PRMT6 regulates RAS/RAF binding and MEF/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation
Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MS, Ma S.
Cell Rep 2018; 25(3): 690-701.
2018
An L, Dong C, Li J, Chen J, Yuan J, Huang J, Chan KM, Yu CH, Huen MS.
PNAS 2018; 115(35): E8286-8295.
2018
C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/beta-catenin signaling
Jiang J, Tang S, Xia J, Wen J, Chen S, Shu X, Huen MS, Deng Y.
Oncogene 2018; 37(22): 2992-3005.
2018
Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38a- and JNK-mediated apoptosis in oesophageal squamous cell carcinoma
Liu J, Lv L, Gong J, Tan Y, Zhu Y, Dat Y, Pan X, Huen MS, Li B, Tsao SW, Huo J, Cheung AL.
Int J Cancer 2018; 142(1): 145-155.
2017
BRCA2 antagonizes classical and alternative non homologous end-joining to prevent gross genomic instability
Han J, Ruan C, Huen MS, Wang J, Xie AY, Fu C, Liu T, Huang J.
Nat Commun 2017; 8(1): 1470.
2017
AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
Lou J, Chen H, Han J, He H, Huen MS, Feng XH, Liu T, Huang J.
Nat Commun 2017; 8(1): 985.
(Recommended by F1000Prime)
(Recommended by F1000Prime)
2017
An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS.
PNAS 2017; 114(14): E2872-2881.
(Recommended by F1000Prime; Highlighted in Science Signaling - "NLS protects DNA damage protein")
(Recommended by F1000Prime; Highlighted in Science Signaling - "NLS protects DNA damage protein")
2017
Guo Y, An L, Ng HM, Sy SM, Huen MS.
J Biol Chem 2017; 292(3): 967-978.
2016
Feng W, Guo Y, Huang J, Deng Y, Zang J, Huen MS.
Cell Discovery 2016; 2:16016.
2016
Ng HM, Wei L, Lan L, Huen MS.
J Biol Chem 2016; 291(31): 16197-207.
2016
Lau WC, Li Y, Liu Z, Gao Y, Zhang Q, Huen MS.
Cell Cycle 2016; 15(8): 1117-1124.
2016
H1 provides the missing link
Huen MS, Chen J.
Cell Res 2016; 26(1):5-6.
2015
Guo Y, Feng W, Sy SM, Huen MS.
J Biol Chem 2015; 290: 27545-56.
2015
Molecular architecture of the Ub-PCNA/Pol eta complex bound to DNA
Lau WC, Li Y, Zhang QF, Huen MS.
Sci Rep 2015; 5:15759.
2015
Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage
Yang J, Deng W, Hau PM, Liu J, Lau VM, Cheung AL, Huen MS, Tsao SW.
Lab Invest 2015; 95(8):937-50.
2015
Covalent inhibition of Ubc13 affects ubiquitin signaling and reveals active site elements important for target
Hodge CD, Edwards RA, Markin CJ, McDonald D, Pulvino M, Huen MS, Zhao J, Spyracopoulos L, Hendzel MJ, Glover JN.
ACS Chem Biol 2015; 10(7):1718-28.
2015
Role of ATM in the formation of replication compartment during lytic replication of EBV in nasopharyngeal epithelial cells
Hau PM, Deng W, Jia L, Yang J, Tsurumi T, Chiang AK, Huen MS, Tsao SW.
J Virol 2015; 89(1):652-68.
2014
The human SRCAP chromatin remodeling complex promotes DNA-end resection
Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J.
Curr Biol 2014; 24(18):2097-110.
2014
F-Box Only Protein (FBXO31) negatively regulates p38 Mitogen-Activated Protein (MAP) kinase signaling by mediating lysine48-linked ubiquitination and degradation of MAP Kinase Kinase 6 (MKK6)
Liu J, Han L, Li B, Yang J, Huen MS, Pan X, Tsao SW, Cheung AL
J Biol Chem 2014; 289(31):21508-18.
2014
SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination
Han J, Liu T, Huen MS, Hu L, Chen Z, Huang J.
J Cell Biol 2014; 205(6):811-27.
2013
Sy SM, Jiang J, O WS, Deng Y, Huen MS.
Nucleic Acids Res 2013; 41(18):8572-80.
2013
Zhang X, Chen J, Wu M, Wu H, Arokiaraj AW, Wang C, Zhang W, Tao Y, Huen MS, Zang J.
Cell Cycle 2013; 12(2):312-21.
2012
Ring Finger Protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage
Chen J, Feng W, Jiang J, Deng Y, Huen MS.
J Biol Chem 2012; 278(33):27715-22.
2012
Nucleolar exit of RNF8 and BRCA1 in response to DNA damage
Guerra-Rebollo M, Mateo F, Franke K, Huen MS, Lopitz-Otsoa F, Rodriguez MS, Plans V, Thomson TM.
Exp Cell Res 2012; 318(18):2365-76.
2012
Fanconi anemia (FA) binding protein FAAP20 stablizes FA complementation group A (FANCA) and participates in interstrand cross-link repair
Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J.
PNAS 2012; 109(12):4491-6.
2012
Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
Shao Z, Li F, Sy SM, Yan W, Zhang Z, Gong D, Wen B, Huen MS, Gong Q, Wu J, Shi Y.
J Struct Biol 2012; 177(2):459-68.
2012
RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage
Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J.
DNA Repair 2012; 11(2):131-8.
2012
Lok GT, Sy SM, Dong S, Ching YP, Tsao SW, Thomson TM, Huen MS.
Nucleic Acids Res 2012; 40(1): 196-205.
2012
Mequindox induced cellular DNA damage via generation of reactive oxygen species
Liu J, Ouyang M, Jiang J, Mu P, Wu J, Yang Q, Zhang C, Xu W, Wang L, Huen MS, Deng Y.
Mutat Res 2012; 741(1-2): 70-5.
2011
The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection
Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J and Chang S.
Nat Struct Mol Biol 2011; 18(12): 1400-7.
2011
Catalytic characteristics of CYP3A22-dependent mequindox detoxification
Liu J, Ge X, Ouyang M, Tang X, Wu J, Wang J, Jiang J, Huen MS, Deng Y.
Catal Commun 2011; 12(7): 637-43.
2011
Roles of histone ubiquitylation in DNA damage signaling
Dong S, Huen MS.
Front Biol 2011; 6(5): 390-7.
2011
Loss of ΔNp63α promotes mitotic exit in epithelial cells
Hau PM, Yip YL, Huen MS, Tsao SW.
FEBS Lett 2011; 585(17):2720-6.
2011
Id1 interacts and stabilizes the Epstein-Barr Virus latent membrane protein 1 (LMP1) in nasopharyngeal epithelial cells
Hau PM, Tsang CM, Yip YL, Huen MS, Tsao SW.
PLoS ONE 2011; 6(6):e21176.
2011
Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability
Chen M, Huang JD, Deng HK, Dong S, Deng W, Tsang SL, Huen MS, Chen L, Zan T, Zhu GX, Guan XY.
BMC Cancer 2011; 11:199.
2011
Sy SM, Jiang J, Dong S, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS.
J Biol Chem 2011; 286(25): 22355-22361.
2010
Sy MS, Chen J, Huen MS.
Nucleus 2010; 1(6):472-4.
2010
Impact of G(2) checkpoint defect on centromeric instability
Deng W, Tsao SW, Mak GW, Tsang CM, Ching YP, Guan XY, Huen MS, Cheung AL.
Oncogene 2011; 30(11):128-9.
2010
SON is a spliceosome-associated factor required for mitotic progression
Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J.
Cell Cycle 2010; 9(13):2679-85.
2010
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
Santos MA, Huen MS, Jankovic M, Chen H, Lopez-Contreras A, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.
J Exp Med 2010; 207(5):973-81.
2010
Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J.
Mol Cell 2010; 37:1-11.
(Recommended by F1000Prime)
(Recommended by F1000Prime)
2010
Huen MS, Sy SM, Chen J.
Nat Rev Mol Cell Biol 2010; 11(2):138-48.
2010
Huen MS, Chen J.
Trends Biochem Sci 2010; 35(2):101-8.
Before July 2009
Cell death caused by single-stranded oligodeoxynucleotide-mediated targeted genome sequence modification
Liu C, Wang Z, Huen MS, Lu LY, Lu DP, Huang JD.
Oligonucleotides 2009;19(3):218-6.
Before July 2009
MRG15 is a novel PALB2 interacting factor involved in homologous recombination
Sy SM, Huen MS, Chen J.
J Biol Chem 2009; 284(32):21127-31.
Before July 2009
PALB2 regulates recombinational repair through chromatin association and oligomerization
Sy SM, Huen MS, Zhu YY, Chen J.
J Biol Chem 2009; 284(27):18302-10.
Before July 2009
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
Sy SM, Huen MS, Chen J.
PNAS 2009; 106(17):7155-60.
(Highlighted in Science – “Complicated Supercomplexes”)
(Highlighted in Science – “Complicated Supercomplexes”)
Before July 2009
RAD18 transmits DNA damage signaling to elicit homologous recombination repair
Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J.
Nat Cell Biol 2009; 11(5):592-603.
(Recommended by F1000Prime)
(Recommended by F1000Prime)
Before July 2009
When loose ends finally meet
Huen MS, Chen J.
Nat Struct Mol Biol 2008;15(12):1241-2.
Before July 2009
Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response
Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X.
Mol Cell Biol 2009; 29(3):849-60.
Before July 2009
Non-canonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly
Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J.
Mol Cell Biol. 2008;28(19):6104-12.
Before July 2009
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis
Minter-Dykhouse K, Ward I, Huen MS, Chen J, Zou L.
J Cell Biol 2008;181(5):727-35.
Before July 2009
Highly efficient deletion method for the engineering of plasmid DNA with single-stranded oligonucleotides
Lu LY, Huen MS, Tai AC, Liu DP, Cheah KS, Huang JD.
Biotechniques 2008;44(2):217-24.
Before July 2009
Direct interaction between SET8 and PCNA couples H4-K20 methylation with DNA replication
Huen MS, Sy SM, van Deursen JM, Chen J.
J Biol Chem 2008; 283(17):11073-7.
Before July 2009
The DNA damage response pathways: at the crossroad of protein modifications
Huen MS, Chen J.
Cell Res 2008; 18(1):8-16.
Before July 2009
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J.
Before July 2009
Active transcription promotes single-stranded oligonucleotide mediated gene repair
Huen MS, Lu LY, Liu DP, Huang JD.
Biochem Biophys Res Commun 2007;353(1):33-9.
Before July 2009
The involvement of replication in single stranded oligonucleotide-mediated gene repair
Huen MS, Li XT, Lu LY, Watt RM, Liu DP, Huang JD.
Nucleic Acid Res 2006;34(21):6183-94.